Cov khoom siv ntshiab Thymosin Beta 4 TB500 / TB-500 fragment cas 885340-08-9

TB500 yog ib tug hluavtaws molecule nyob rau hauv lub active cheeb tsam ntawm thymosin beta 4. TB500 txhawb endothelial cell txawv, angiogenesis nyob rau hauv cov ntaub so ntswg dermis, cell migration, collagen deposition thiab txo o.Txhais angiogenesis (ANG), 14,124 Da protein cuam tshuam nrog angiogenesis hauv cov qog nqaij hlav.Nws yog secreted los ntawm qog hlwb, uas yog zoo inducers rau tsim cov hlab ntsha tshiab.
Cov yam ntxwv ntawm cov qauv Acharya et al.txiav txim siab cov qauv siv lead ua ntawm tib neeg antigens ntawm 2.4 0 A. Cov qauv tag nrho muaj lub raum zoo li peb npaug ntawm qhov nco txog RNaseA.Lub chaw ua haujlwm RNA lysis (His-13, His-114 thiab Lys-40) thiab qhov chaw ua haujlwm hypothetical receptor binding, ob lub luag haujlwm tseem ceeb ntawm kev lom neeg sib txawv ntawm Rnase A 5. Lub hauv paus tseem ceeb ntawm cov molecule muaj ib khub ntawm P- cov qauv nrog kev sib txuam tsis sib xws, tsim cov topology tseem ceeb, nrog cov seem hauv paus Ser-72 thiab Gly-99 ntawm qhov vertices.Lub ntsiab flaky qauv yog ua tiav los ntawm ob txoj hlua ntxiv ntawm ob sab ntawm cov saw hauv nruab nrab (cov seem 41-47; 111-116).Muaj 3 helix H1, residual 3-14, H2, residual 22-33 thiab H3, thiab residual 49-58.